Retinal Therapeutics Lab

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Gregory-Evans Retinal Therapeutics Lab 2011. From left to right: Chris Laver (PhD student); Emran Bashar (PhD student); Kevin Gregory-Evans (PI); Andrew Metcalfe (Research Assistant); Anat Yanai (Senior Research Associate)

The overall theme for the Gregory-Evans Retinal Therapeutics Lab is to identify new ways of treating common retinal diseases, such as macular degeneration and retinitis pigmentosa. This work will focus on novel cell-based therapeutic strategies in model systems (e.g. rodents models of eye disease) and clinical trials. We are undertaking a number of projects to look at how cells can be used to replace damaged retinal tissue and also new ways that cells can be used to deliver and secrete drugs long-term into the diseased retina to prevent further decline of vision.

Past & Present Lab Members

Post-doctoral Research Associates

1. Jim Bellingham (1998-2000)
2. Emma Tartellin (1999-2002)
3. Matt Hodges (1999-2002)
4. Matt Williams (2003-2005)
5. Donna Mackay (2005-2007)
6. Diana Hernandez (2005-2006)
7. Matt Hodges (2006-2008)
8. Anat Yanai (2010-present)

Research Assistants

1. Francis Chang (2007-2009)
2. Kelvin Po (2009-2010)
3. Andrew Metcalf (2010-present)

PhD Students

1. Lindsey Bibb (awarded 2003)
2. Helena Vieira (awarded 2003)
3. James Blackburn (awarded 2004)
4. Julian Patterson (October 2005 – present)
5. AMA Emran Bashar (2011-present)
6. Chris Laver (2011-present)

Collaborators

International:

National:

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Illustration A. Cell-based drug delivery in the S334ter-4 transgenic model of retinitis pigmentosa. Light microscopy sections at P70. A,B: untreated, C,D : treated with daily subcutaneous gentamicin E,F intravitreal injection of GDNF-secreting mES cells; G,H : combination of both these treatment strategies; I,J : unaffected control Sprague-Dawley rat. Top panels (A,C,E,G,I): sections from upper hemisphere, peripheral retina. Bottom panels (B,D,F,H,J): sections from upper hemisphere, central retina. ONL=outer nuclear layer; IOS=photoreceptor inner and outer segments. ( Ophthal Res 2011;47:32-38).

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Illustration B. Magnetised stem cells (labeled red) after intravitreal (A,B) or intravenous (C,D) injection, can be localized to a specific retinal locus with a magnet placed within the orbit on the outer surface of the eye (white dashed circle). Cells localize in the inner retina after intravitreal injection (B) but will also accumulate in the outer retina (D) if cells are delivered via intravenous injection. A&C: flatmount rodent retina. B&D: cross-sectional views of treated retina.

Position Available:

Research Associate Position at Retinal Therapeutic laboratory

The Department of Ophthalmology and Visual Sciences at the University of British Columbia seeks applications for a Research Associate in retinal therapeutic lab.

The successful candidate will lead research projects that use research strategies to transplant the photoreceptor precursor in animal model and find out the functional benefits.

The duties include to plan, organize and conduct experiments in line with the objectives of the research to evaluate the effectives of small molecules to long term survival of transplanted neurosensory stem cells.

The candidate will be required to interact with graduate students and research technician and coordinate the efforts of lab members in conjunction with the Principle Investigator.

Requirements:

The successful candidate will hold a Ph.D. Biology, Cell Biology, or related field and a minimum of 5 years of postdoctoral research experience.

The candidate will be expected to supervise and mentor graduate students and research technicians in the laboratory, requiring experience and demonstration of strong project management skills and providing hands-on assistance to trainees.

The candidate must be experienced in the functional techniques, optokinetic tracking, electroretinography, optical coherence tomography and drug delivery system.

The candidate must have expertise in the areas of molecular biology, cell biology, and histological analyses

The candidate must have background and practical experience of cell culture and working knowledge of laboratory animal system.

The candidate should have a strong track record in scientific publications.

The candidate should have demonstrated grant writing skills with a proven record of an ability to attract funding.

The candidate should be highly collaborative, self-motivated, team-oriented, and have excellent communication skills.

Please email your cover letter and CV to Prof. Kevin Gregory-Evans at kge30@mail.ubc.ca by the closing date is May 24, 2017.